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Current Advances in Peptide Synthesis

Glycine Amino Acid Biology Chemistry Science

Amino acids are the building blocks of peptides and proteins

Current advances in peptide synthesis have however permitted us to mimic this process in nature by preparing various peptides having various biological functions and conformations. The self-assembly of peptides is gaining a huge interest in the field of Nano biotechnology. These peptides demonstrate several striking features and can be used in tissue regeneration, biological surface engineering, as well as in antibiotics, cosmetic industry and food science. Here is all you need to know about the current advances in peptide synthesis. There are its structures and applications.

Structure

  • Dipeptides – The simplest building blocks of peptide are dipeptides.
  • Lego peptides / Ionic self-complementary peptides

They are about 5 nm size and have 16 amino acids. Lego peptides have the distinct characteristics of having two distinct surfaces which is either hydrophobic or hydrophilic.

Surfactant peptides

Surfactant –like peptides form nanotubes and Nano vesicles by undergoing self-assembly in water. They are mimicked from natural lipids. They have a hydrophilic head and a hydrophobic tail. Monomers are 2-3 nm in legth and they consist of amino acids. Its length can be changed with the addition or removal of acids. This is one of its main properties.

  • The self-assembly on the surface and form monolayers which are just few nanometers thick.

Application

  • LEGO peptides are widely used for 3D cell culturing as they resemble the porosity and the structure of extra-cellular matrices
  • By studying the behavior of switch peptides, interaction between various proteins can be studied leading to more understanding of diseases such as Parkinson’s and Alzheimer’s.
  • Surfactant peptides can be used as targeting delivery systems for RNAi, drugs. Molecular ‘switches’ peptides can be converted into Nano switches when an electronic component is incorporated

 

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